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. 2022 Sep 6;13:5249. doi: 10.1038/s41467-022-32975-w

Fig. 6. NIR-II SERS imaging of a solid tumor in a living tumor-bearing mouse.

Fig. 6

a Schematic representation of NIR-II SERS probes for in vivo SERS imaging of tumors. NIR-II SERS probes were intravenously administrated into a 4T1 tumor-bearing mouse, and thereby effectively accumulated in the tumor. b (i) Optical photograph, (ii) ex vivo NIR-II SERS image and (iii) representative SERS spectra at points 1 and 2 within and outside a tumor excised from a tumor-bearing mouse at 12 h post-administration of NIR-II SERS probes. c (i) Optical photograph of a 4T1 tumor-bearing mouse intravenously administrated with NIR-II SERS probes, (ii) zoom-in optical photograph of the tumor for in vivo NIR-II SERS imaging and (iii) the corresponding NIR-II SERS image of the tumor site directly taken from the mouse at 12 h post-administration, and (iv) representative SERS spectra at points 1, 2, and 3 as indicated in the SERS image (iii).