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. 2022 Sep 7;11(1):52. doi: 10.1038/s41389-022-00425-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a 2SC and AKR1B10 antibodies can both act as biomarkers for FH-deficiency. Immunohistochemistry showed strong staining with both antibodies in FH-deficient tumors. It also revealed a subgroup of tumors positive only for AKR1B10 (AKR1B10hi). Histopathological evaluation of the AKR1B10hi tumors showed increased cellularity in most of them. Myometrium was negative for both AKR1B10 and 2SC. b Half of the AKR1B10hi tumors showed two or more features associated with FH-deficiency [37], including eosinophilic inclusions (top left), staghorn vasculature (top right), eosinophilic nucleoli and nuclear atypia (bottom left), and alveolar edema (bottom right). Example of eosinophilic nucleoli is marked with an arrow. c Half of the AKR1B10hi samples displayed perivascular hypercellularity, a feature not associated with leiomyomas previously. Magnification 100× (left) and 200× (right).