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. 2022 Sep 6;12:366. doi: 10.1038/s41398-022-02124-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — During Phase I, A CYP2C19 and B CYP2D6 IM + PMs showed lower mean S-DCT_ad/ESC_adj ratio relative to NMs. Likewise, during Phase II, in the ESC-Only and ESC + ARI treatment arms, C CYP2C19 IM + PMs compared to NMs had lower mean S-DCT_ad/ESC_adj ratio in serum. D For CYP2D6, IM + PMs displayed lower S-DCT_ad/ESC_adj ratio in ESC-Only, whereas S-DCT_ad/ESC_adj ratio was not associated with CYP2D6 metabolizer group in the ESC + ARI treatment arm. All linear regression analyses were adjusted for age, ancestry, sex, site, time since last dose, CYP2C19 and CYP2D6 metabolizer groups. Error bars represent standard error. ARI aripiprazole, ESC escitalopram, IM intermediate metabolizer, NM normal metabolizer, PM poor metabolizer, RM rapid metabolizer, UM ultra-rapid metabolizer. *q < 0.05; **q < 0.01; ***q < 0.001.