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. 2022 Aug 24;13:933364. doi: 10.3389/fphar.2022.933364

FIGURE 3.

FIGURE 3

Effects of Zn-deficient diet and CRS on the antidepressant-like activities of three doses of atypical antidepressant compounds (ketamine: 10 mg/kg, Ro 25–6981: 10 mg/kg, Hyp: 2.5 mg/kg + Lan: 10 mg/kg) in the SPT and TST in mice. (A) Experimental schedule of drug treatments and behavioral tests. (B) SPT was performed 24 h after the last treatment. (C) TST was performed 72 h after the last treatment. All values are expressed as mean ± SEM. The data were analyzed by one-way ANOVA and Newman–Keuls multiple comparison test. (B) F (8, 92) = 3,948; p < 0.0005; *p < 0.05; **p < 0.01 vs. Con, #p < 0.05 vs. CRS, @ p < 0.05 vs. CRS + ZnD, n = 9–12; (C) F (8, 98) = 3,247; p = 0.0025; ### p < 0.001 vs. CRS + ZnD, n = 10–13. Con: control, ZnD: zinc deficient diet, CRS: chronic restraint stress, Hyp: hyperforin, Lan: lanicemine, SPT: sucrose preference test, TST: tail suspension test.