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. 2022 Aug 24;13:933364. doi: 10.3389/fphar.2022.933364

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(A) Experimental schedule of drug treatment. (B,C) Metabolite-to-parent ratios of maximum concentrations (C_max; left panel) and areas under the curves (AUCs; right panel) in the control and study groups. (D,E) Tissue-to-serum ratios of C_max (left panel) and AUCs (right panel) for ketamine in the control and study groups. (F,G) Tissue-to-serum C_max (left panel) and AUCs (right panel) for (2R,6R;2S,6S)-HNK in the control and study groups. CRS: chronic restraint stress, FC: frontal cortex, Hp: hippocampus, ZnD: zinc deficient diet.