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. 2022 Aug 24;10:902225. doi: 10.3389/fcell.2022.902225

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Copyright © 2022 Hekmatnejad and Rudnicki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Satellite cell heterogeneity. Satellite cells can give rise to both myogenic and brown adipogenic lineages. miR-133 expression is upregulated as the myogenic program progresses. Prdm16 regulates satellite cell differentiation into brown adipocytes and its expression is inhibited by miR-133. Thereby, miR-133 controls brown adipose determination (dashed arrow). Subsets of satellite cells have differing functional potential (black arrows). Pax7⁺/Myf5⁻, Pax7^high, and long-term label-retaining populations have the ability to repopulate the stem cell pool. Furthermore, Pax7⁺/Pax3⁺ is a rare subpopulation that is resistant to radiation and contains reserve stem cell properties. LRC, label-retaining cells; non-LRC, non-label-retaining cells; SCs, satellite cells.