TABLE 1.
Major molecular participants underlying neurodevelopmental processes of angiogenesis, BBB formation, and neurogenesis.
| Process | Key signaling molecules/pathways | References |
|---|---|---|
| Angiogenesis | - Hypoxia-Inducible Factors (HIFs) | (Semenza, 2014, 2020; Abeyrathna and Su, 2015) |
| - VEGF/NOTCH signaling | (Jakobsson et al., 2010; Walchli et al., 2015; Paredes et al., 2018) | |
| - WNT/ß-catenin signaling | (Martowicz et al., 2019) | |
| - Non-canonical WNT ligands | (Korn et al., 2014) | |
| - Unfolded Protein Response (UPR) signaling | Zhuang et al. (2017) | |
| - Nuclear Factor-Kappa B (NF-kB) | (Tabruyn and Griffioen, 2008; Binet and Sapieha, 2015) | |
| BBB formation | - NOTCH signaling pathway | Derada Troletti et al. (2018) |
| - Canonical WNT signaling pathway | (Liebner et al., 2008; Blanchette and Daneman, 2015; Guérit et al., 2021) | |
| - Nuclear Factor-Kappa B (NF-kB) | Volk et al. (2019) | |
| Neurogenesis | - WNT signaling pathway | (Coullery et al., 2016; Arredondo et al., 2020) |
| - AKT/mTOR pathway | (Götz and Huttner, 2005; Abe et al., 2010; Polchi et al., 2018) | |
| - Nuclear Factor-Kappa B (NF-kB) | (Y. Zhang and Hu, 2012) | |
| - Unfolded Protein Response (UPR) signaling | (Shim et al., 2004; Hayashi et al., 2008; Murao and Nishitoh, 2017) |