FIGURE 1.

Transcriptional regulation of G6PD. The cartoon diagram on display consists of three main parts. On the left, activation of NF-ĸB in response to cellular stresses or the PIEKA-FYN complex leads to the phosphorylation and activation of STAT3, which results in the translocation of p-STAT3 to the nucleus and binding to the G6PD promoter enhancing transcription. In the middle section, signals regulate the expression of HMGA1 to promote G6PD transcription. On the right side, HBV protein forms a complex with intracellular protein p62 and KEAP1, resulting in translocation of NRF2 into the nucleus to promote G6PD expression. At the bottom, methylation and acetylation of histones are involved in transcriptional regulation of G6PD.