Table 2.
Clinical characteristics of patients of the included studies (when obtained from original article).
| Article | Age | Smoking status (%) | Alcohol intake (%) | Men/women |
|---|---|---|---|---|
| Oral/oropharyngeal HPV infection in healthy patients | ||||
| Sacramento (2006)6 | Mean of 25 y | 14.3% | 71.4% | 21/29 |
| Esquenazi (2010)7 | Mean of 23 y | 3.0% | 3.0% | 40/60 |
| Horewicz (2010)8 | Mean of 38 y | 3.8% | – | 28/76 |
| Tristão (2012)9 | Predominantly between 18 and 21 y | – | – | 37/88 |
| Kreimer (2013)10 | 47% under 30 y 83% under 44 y |
40.0% | 74.0% | 499/0 |
| Cavenaghi (2013)5 | Mean of 51 y | 75.0% | 37.1% | 77/47 |
| Araujo (2014)11 | Mean of 36 y | 6.6% | 23.5% | 63/103 |
| Machado (2014)12 | Mean of 23 y | – | – | 0/514 |
| Weighted average | 30 years | 318/1043 (30.5%) | 493/939 (52.5%) | – |
| Oral/oropharyngeal HPV infection in patients with benign or premalignant lesions | ||||
| Fonseca-Silva (2012)14 | Means: 32 y (control); 54 y (dysplasia) | 56.9% | 61.1% | 39/33 |
| HPV infection in oral cavity and/or oropharyngeal squamous cell carcinoma patients | ||||
| Comparative studies (healthy people versus SCC patients) | ||||
| Cortezzi (2004)15 | Mean of 61 y | – | – | 106/52 |
| Silva (2007)16 | Over 40 y | 100.0% | – | – |
| Comparative studies (benign lesions versus SCC patients) | ||||
| Lira (2010)22 | Mean of 57 y | 80.2% | 66.3% | 71/15 |
| Population studies | ||||
| Miguel (1998)24 | Mean of 61 y | 90.5% | – | 42/3 |
| Soares (2007)25 | Mean of 65 y | – | – | 49/26 |
| Oliveira (2008)26 | Mean of 59 y | 81.6% | – | 73/14 |
| Simonato (2008)27 | 79.3% under 60 y | 89.7% | 62.1% | 27/2 |
| Soares (2008)28 | Mean of 65 y | – | – | – |
| Oliveira (2009)29 | 59% over 60 y | – | – | 57/31 |
| Pereira (2011)30 | Mean of 63 y | – | – | 19/8 |
| Spindula-Filho (2011)31 | 55.3% over 65 y | 72.3% | 61.7% | 34/13 |
| Cordeiro-Silva (2012)32 | 44.5% over 58 y | 80.0% | 68.9% | 35/10 |
| Kaminagakura (2012)33 | Mean of 51 y | 84.0% | 62.0% | 81/33 |
| Marques-Silva (2012)34 | 33.3% under 45 y | 96.0% | 93.3% | 34/6 |
| Cantarutti (2014)35 | Mean of 56 y | 92.0% | 65.0% | 16/10 |
| Lopez (2014)36 | 45% under 55 y | 93.7% | 95.6% | – |
| Weighted average | 59 years | 703/801 (87.8%) | 458/609 (75.2%) | – |
| Oral/oropharyngeal HPV infection in patients with genital HPV infection | ||||
| Comparative studies (healthy people versus patients with genital HPV infection) | ||||
| Gonçalves (2006)37 | Mean of 30 y | 29.3% | – | 0/140 |
| Marques (2013)38 | Mean of 45 y | – | – | 21/43 |
| Ribeiro (2014)39 | Mean of 32 y | 27.4% | – | 31/31 |
| Vidotti (2014)40 | 41.9% under 30 y | 7.6% | 33.3% | 0/105 |
| Population studies | ||||
| Castro (2009)41 | Mean of 28 y | 30.0% | 0.0% | 0/30 |
| Xavier (2009)42 | Mean of 29 y | – | – | 30/0 |
| Peixoto (2011)43 | Mean of 30 y | 15.0% | 88.1% | 0/100 |
| Zonta (2012)44 | 74.1% under 35 y | 66.7% | – | 0/27 |
| Weighted average | 32 years | 90/437 (20.6%) | 123/235 (52.3%) | – |
| Oral/oropharyngeal HPV infection in immunodeficient patients (all comparative studies with healthy people) | ||||
| Lima (2014)46 | Mean of 36 y | 31.0% | 50.0% | 0/200 |
| Weighted average | 36 years | 62/200 (31.0%) | 100/200 (50.0%) | – |