Table 4.
Comparison of Clinicopathological Characteristics according to Age at Diagnosis and TERT Promoter Mutation Status in 2,020 Papillary Thyroid Carcinoma Patients
| Clinical characteristic | Age <55 years (n=1,520) |
Age ≥55 years (n=500) |
||||
|---|---|---|---|---|---|---|
| Mutation-type (n=12) | Wild-type (n=1,508) | P value | Mutation-type (n=45) | Wild-type (n=455) | P value | |
| Age, yr | 46.8±5.9 | 39.7±8.7 | 0.005 | 67.8±8.3 | 62.0±5.7 | <0.001 |
| Sex | ||||||
| Female | 5 (41.7) | 1,115 (73.9) | 0.019 | 27 (60.0) | 337 (74.1) | 0.043 |
| Male | 7 (58.3) | 393 (26.1) | 18 (40.0) | 118 (25.9) | ||
| Tumor size, cm | 1.57±1.17 | 1.22±0.97 | 0.202 | 3.17±1.68 | 1.17±0.91 | <0.001 |
| 0.1–1.0 | 3 (25.0) | 877 (58.2) | 0.060 | 3 (6.7) | 260 (57.1) | <0.001 |
| 1.1–2.0 | 7 (58.3) | 428 (28.4) | 12 (26.7) | 148 (32.5) | ||
| 2.1–3.0 | 1 (8.3) | 118 (7.8) | 10 (22.2) | 27 (5.9) | ||
| 3.1–4.0 | 0 | 47 (3.1) | 9 (20.0) | 13 (2.9) | ||
| 4.1–5.0 | 1 (8.3) | 21 (1.4) | 3 (6.7) | 1 (0.2) | ||
| 5.1–8.5 | 0 | 17 (1.1) | 8 (17.8) | 6 (1.3) | ||
| Pathologic T category | ||||||
| T1 | 6 (50.0) | 1,246 (82.6) | <0.001 | 10 (22.2) | 391 (85.9) | <0.001 |
| T2 | 1 (8.3) | 139 (9.2) | 4 (8.9) | 35 (7.7) | ||
| T3 | 3 (25.0) | 111 (7.4) | 11 (24.4) | 26 (5.7) | ||
| T4 | 2 (16.7) | 12 (0.8) | 20 (44.4) | 3 (0.7) | ||
| Pathologic N categorya | ||||||
| Nx | 3 (25.0) | 223 (14.8) | >0.999 | 4 (8.9) | 92 (20.2) | <0.001 |
| N0 | 4 (33.3) | 536 (35.5) | 11 (24.4) | 196 (43.1) | ||
| N1a | 4 (33.3) | 530 (35.1) | 9 (20.0) | 118 (25.9) | ||
| N1b | 1 (8.3) | 219 (14.5) | 21 (46.7) | 49 (10.8) | ||
| Initial distant metastasis | ||||||
| Absent | 12 (100.0) | 1,494 (99.1) | >0.999 | 40 (88.9) | 453 (99.6) | <0.001 |
| Present | 0 | 14 (0.9) | 5 (11.1) | 2 (0.4) | ||
| TERT promoter mutation | ||||||
| C228T mutation | 10 (83.3) | - | 40 (88.9) | - | ||
| C250T mutation | 2 (16.7) | - | 4 (8.9) | - | ||
| C228A mutation | 0 | - | 1 (2.2) | - | ||
Values are expressed as mean±standard deviation or number (%).
TERT, telomerase reverse transcriptase.
a
Nx patients were not included in the chi-square test.