Table 5.
Comparison of Clinicopathological Characteristics according to the Type of TERT Promoter Mutations in 71 Patients
| Clinical characteristic | C228T (n=64) | C250T (n=7) | P value |
|---|---|---|---|
| Age, yr | 63.0±13.1 | 56.7±10.3 | 0.222 |
| <55 | 14 (21.9) | 3 (42.9) | 0.346 |
| ≥55 | 50 (78.1) | 4 (57.1) | |
| Sex | |||
| Female | 37 (57.8) | 4 (57.1) | >0.999 |
| Male | 27 (42.2) | 3 (42.9) | |
| Tumor size, cm | 3.3±2.0 | 2.6±1.4 | 0.363 |
| Pathologic T category | |||
| T1 | 18 (28.1) | 1 (14.3) | 0.796 |
| T2 | 5 (7.8) | 1 (14.3) | |
| T3 | 18 (28.1) | 2 (28.6) | |
| T4 | 23 (35.9) | 3 (42.9) | |
| Pathologic N categorya | |||
| Nx | 11 (17.2) | 2 (28.6) | >0.999 |
| N0 | 18 (28.1) | 2 (28.6) | |
| N1a | 14 (21.9) | 1 (14.3) | |
| N1b | 21 (32.8) | 2 (28.6) | |
| Initial distant metastasis | |||
| Absent | 52 (81.3) | 7 (100.0) | 0.593 |
| Present | 12 (18.8) | 0 | |
| Histological type | |||
| Papillary thyroid carcinoma | 50 (78.1) | 6 (85.7) | 0.477 |
| Follicular thyroid carcinoma | 7 (10.9) | 0 | |
| Hurthle cell thyroid carcinoma | 1 (1.6) | 0 | |
| Poorly differentiated thyroid carcinoma | 2 (3.1) | 1 (14.3) | |
| Anaplastic thyroid carcinoma | 4 (6.3) | 0 |
Values are expressed as mean±standard deviation or number (%).
TERT, telomerase reverse transcriptase.
a
Nx patients were not included in the chi-square test.