TABLE 7.

Trough concentration and AUC cut-off points for AKI occurrence and the reported area under the ROC curve values.

Pharmacokinetic parameter	Cut-off point for AKI	Area under the ROC curve (AUC)	Sensitivity (%)	Specificity (%)
Trough concentration 1	16.78 μg/ml	0.861	88.9	90.9
Trough concentration 2	15.86 μg/ml	0.859	88.9	86.4
Mean trough concentration	16.92 μg/ml	0.866	88.9	90.9
AUCτ	355.19 μg h/ml	0.844	66.7	94.6
AUC24h	710.38 μg h/ml	0.844	66.7	94.6
k	0.06 h−1	0.667	88.9	43.2