Table 5.

Association between LTC4S, NOS2A, and PTGDR gene polymorphisms and nasal polyps (NP), NP and atopy, NP and asthma, aspirin triad, and nonsteroidal anti-inflammatory drug intolerance (NSAIDi).

	NP	NP + atopy	NP + asthma	Aspirin triad	NSAIDi
−444 A > C LTC4S		+(p = 0.033)	+(p = 0.012)
NOS2A VNTR: CCTTT (>14×)			+(p = 0.034)	+(p = 0.005)	+(p = 0.009)
PTGDR CCCT/CCCC	+(p = 0.043)		+(p = 0.013)	+(p = 0.041)

LTC4S, leukotriene C4 synthase; NOS2A, nitric oxide synthase; VNTR, variable number tandem repeat; PTGDR, prostaglandin D2 receptor.

Source: Adapted from Benito Pescador et al. (2012).¹²