Table 3.
Results of association tests with IRF6 rs2235375 SNP in cleft lip and palate.
| IRF6 rs2235375 | OR (95% CI) | p-value |
|---|---|---|
| Overall clefts | ||
| GG | Reference | 0.085a |
| GC | 1.53 (0.95–2.44) | 0.077 |
| CC | 1.86 (1.00–3.47) | 0.047 |
| GC + CC vs. GG | 1.19 (1.03–2.51) | 0.034 |
| G allele | Reference | |
| C allele | 1.40 (1.04–1.90) | 0.028 |
| CL/P | ||
| GG | Reference | 0.334a |
| GC | 1.33 (0.81–2.16) | 0.225 |
| CC | 1.56 (0.81–2.99) | 0.18 |
| GC + CC vs. GG | 1.38 (0.88–2.19) | 0.163 |
| G allele | Reference | |
| C allele | 1.27 (0.93–1.75) | 0.137 |
| CPO | ||
| GG | Reference | 0.014a |
| GC | 3.92 (1.26–12.21) | 0.021 |
| CC | 5.54 (1.54–19.95) | 0.004 |
| GC + CC vs. GG | 4.33 (1.44–12.97) | 0.005 |
| G allele | Reference | |
| C allele | 2.25 (1.28–3.96) | 0.003 |
IRF6, interferon regulatory factor-6; OR, odds ratio; CI, confidence interval.
a
P Value from a chi-square (df = 2).