Table 3.
Summary of effect of BMI on head and neck cancer patients.
| Authors, Years | BMI categories | Treatment modality | Effect of BMI |
|---|---|---|---|
| Takenaka et al.,15 2015 | Obese or overweight (25 kg/m2), normal (18.5 kg/m2 and <25 kg/m2), and underweight (<18.5 kg/m2). | Surgery, CRT, RT | 192 surgically treated patients no statistically significant the effect of BMI on overall survival. |
| In other treatment modalities high BMI was associated with a better prognosis. | |||
| Huang PY et al.,17 2013 | Obese (27.5 kg/m2), overweight (23.0–27.4 kg/m2), normal weight (18.5–22.9 kg/m2), underweight (<18.5 kg/m2). | IC + CCRT | Higher BMI was associated with increased failure free survival and overall survival. |
| IC + RT | No influence on the risk of locoregional recurrences. | ||
| Lin YH et al.,18 2015 | Two groups (<23 kg/m2 vs. ≥23 kg/m2) | IMRT, CCRT, RT/CCRT + IC | BMI was not significantly associated with overall survival, disease specific survival, distant metastasis free survival, or locoregional free survival. |
| van Bokhorst–de van der Schuer B. et al.,21 1999 | BMI not calculated, Percentage of weight loss during the 6 months before treatment, the percentage of ideal body weight, serum albumin, total lymphocyte count, nutritional index, and bioelectrical impedance analysis. | Surgery | None of the studied nutritional parameters were associated with survival. |
| Present study | Morbid obese (>40 kg/m2), obese (31–40 kg/m2), overweight (26–30 kg/m2), normal weight (18.5–25 kg/m2), underweight (<18.5 kg/m2). | Surgery | BMI was not significantly associated with overall survival, disease free survival |
CRT, chemoradiation therapy; RT, radiation therapy; CCRT, concurrent CRT; BMI, body mass index; IC, induction chemotherapy; IMRT, intensity-modulated radiotherapy.