TABLE 3.

The effect estimates of MR analyses.

Risk factors	Outcomes	MR methods	OR	95% CI lower	95% CI upper	p Value
CD	CRC	MR Egger	1.0001851	0.998845	1.001527	0.78
		Inverse variance weighted (multiplicative random effects)	0.9996213	0.9991	1.00014	0.15
		Inverse variance weighted (fixed effects)	0.9996213	0.99912	1.00012	0.14
		Weighted median	0.9998874	0.99905	1.00072	0.79
		MR RAPS	0.9996161	0.99911	1.00012	0.14
UC	CRC	MR Egger	0.99984	0.997934	1.00175	0.87
		Inverse variance weighted (multiplicative random effects)	0.9998	0.9991	1.0005	0.58
		Inverse variance weighted (fixed effects)	0.9998	0.99918	1.00042	0.53
		Weighted median	0.9998061	0.9988	1.00081	0.71
		MR RAPS	0.9997962	0.99916	1.00043	0.53
IBD	CRC	MR Egger	1.0001262	0.997433	1.002827	0.93
		Inverse variance weighted (multiplicative random effects)	0.999585	0.99869	1.00048	0.36
		Inverse variance weighted (fixed effects)	0.999585	0.99887	1.0003	0.26
		Weighted median	0.9996918	0.99854	1.00085	0.60
		MR RAPS	0.9995729	0.99885	1.0003	0.25
CRC	CD	MR Egger	5.45E-23	7.86E-55	3.79E+09	0.16
		Inverse variance weighted (multiplicative random effects)	1.0798477	0.00049	2372.38304	0.98
		Inverse variance weighted (fixed effects)	1.0798477	0.00403	289.31816	0.98
		Weighted median	0.1966456	0.00019	200.11424	0.65
		MR RAPS	1.081815	0.00375	312.40734	0.98
CRC	UC	MR Egger	4.32E-20	2.74E-51	6.81E+11	0.19
		Inverse variance weighted (multiplicative random effects)	0.2711656	0.00014	528.3707	0.74
		Inverse variance weighted (fixed effects)	0.2711656	0.00267	27.49149	0.58
		Weighted median	0.0233731	0.00007	8.20181	0.21
		MR RAPS	0.259751	0.00245	27.49431	0.57
CRC	IBD	MR Egger	3.24E-21	9.76E-59	1.07E+17	0.22
		Inverse variance weighted (multiplicative random effects)	0.4710136	0.0001	2242.94159	0.86
		Inverse variance weighted (fixed effects)	0.4710136	0.00146	152.34891	0.80
		Weighted median	0.0582004	0.00004	95.9504	0.45
		MR RAPS	0.4617744	0.00133	160.20998	0.80