. 2022 Aug 24;13:949325. doi: 10.3389/fgene.2022.949325

TABLE 4.

Tests of MR-Steiger casual direction, MR-Egger I², heterogeneity and pleiotropy.

Risk factors	Outcomes	Heterogeneity test				MR-Egger interception	p Value	MR-steiger casual direction	MR-egger I²
Risk factors	Outcomes	MR methods	Q	p Value	I²	MR-Egger interception	p Value	MR-steiger casual direction	MR-egger I²
CD	CRC	MR-Egger	112.7	0.26	0.08	-7.74E-05	0.37	TRUE	0.99
CD	CRC	Inverse variance weighted	113.6	0.27	0.08	-7.74E-05	0.37	TRUE	0.99
UC	CRC	MR-Egger	141.8	0.03	0.22	-4.17E-06	0.96	TRUE	0.99
UC	CRC	Inverse variance weighted	141.8	0.03	0.21	-4.17E-06	0.96	TRUE	0.99
IBD	CRC	MR-Egger	105.9	0.00	0.36	-6.02E-05	0.67	TRUE	0.98
IBD	CRC	Inverse variance weighted	106.2	0.00	0.35	-6.02E-05	0.67	TRUE	0.98
CRC	CD	MR-Egger	0.6	0.73	0.00	0.13	0.15	TRUE	0.97
CRC	CD	Inverse variance weighted	5.7	0.13	0.47	0.13	0.15	TRUE	0.97
CRC	UC	MR-Egger	2.8	0.24	0.29	0.11	0.19	TRUE	0.97
CRC	UC	Inverse variance weighted	8.1	0.04	0.63	0.11	0.19	TRUE	0.97
CRC	IBD	MR-Egger	2.6	0.27	0.23	0.12	0.23	TRUE	0.97
CRC	IBD	Inverse variance weighted	6.4	0.09	0.53	0.12	0.23	TRUE	0.97