Table 1.
Patient characteristics.
| Training set | Validation set | |||
|---|---|---|---|---|
| CCA (n = 30) | Control (n = 30) | CCA (n = 20) | Control (n = 20) | |
| Age (yr) | 61.7 ± 8.8 | 61.0 ± 9.6 | 58.6 ± 9.9 | 59.8 ± 10.3 |
| Male | 16 | 16 | 11 | 11 |
| Female | 14 | 14 | 9 | 9 |
| HBV | 7 | 9 | 4 | 6 |
| Overweight | 2 | 3 | 2 | 1 |
| Diabetes | 2 | 4 | 1 | 2 |
| Hypertension | 5 | 4 | 3 | 3 |
| Acute cholangitis | 1 | 11 | 0 | 4 |
| CA19-9 positive | 19 | 5 | 13 | 2 |
| Maximal tumor size (cm) | 2.7 ± 2.2 | NA | 2.2 ± 1.9 | NA |
| Tumor stage | ||||
| I-II | 20 | NA | 12 | NA |
| III-IV | 10 | NA | 8 | NA |
| Differentiation | ||||
| High/moderate | 18 | NA | 13 | NA |
| Low | 12 | NA | 7 | NA |
| Vascular invasion | ||||
| Macro- | 2 | NA | 2 | NA |
| Micro- | 13 | NA | 8 | NA |
| Location | ||||
| Intrahepatic | 18 | NA | 11 | NA |
| Extrahepatic | 12 | NA | 9 | NA |
| Treatment | ||||
| Hepatectomy + chemo | 11 | NA | 7 | NA |
| Whipple + chemo | 13 | NA | 9 | NA |
| Chemo | 6 | NA | 4 | NA |
| Resection margin | ||||
| R0 | 18 | NA | 12 | NA |
| R1 | 6 | NA | 4 | NA |
Overweight: BMI>25; Acute cholangitis was defined as fever, abdominal pain, and jaundice;
Tumor stage was defined according to the TNM classification for CCA in the American Joint Committee on Cancer Staging manual (8th edition);
CA19-9, carbohydrate antigen 19-9; CA19-9 positive: > 37 U/ml; chemo, chemotherapy;
CCA, cholangiocarcinoma; HBV, hepatitis B virus; NA, not available.