Table 4.
Potential biomarkers of CCA.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| P | OR (95%CI) | P | OR (95%CI) | |
| Serum CA19-9 > 37 U/ml | <.001 | 8.636 (2.566, 29.07) | ||
| Bile CEA > 25 ng/ml | 0.044 | 3.763 (1.038, 13.65) | ||
| Serum exosomal miR-141-3p | 0.011 | 4.030 (1.372, 11.84) | ||
| Serum exosomal miR-200a-3p | 0.003 | 5.444 (1.804, 16.43) | ||
| Serum exosomal miR-200c-3p | 0.003 | 5.675 (1.841, 17.49) | ||
| Bile exosomal miR-141-3p | 0.005 | 4.750 (1.584, 14.25) | ||
| Bile exosomal miR-200a-3p | <.001 | 11.67 (3.384, 40.22) | 0.027 | 5.581 (1.213, 25.68) |
| Bile exosomal miR-200b-3p | <.001 | 11.00 (3.292, 36.75) | ||
| Bile exosomal miR-200c-3p | <.001 | 32.50 (7.818, 135.1) | <.001 | 20.69 (4.631, 92.43) |
| Bile exosomal ENST00000588480.1 | 0.006 | 4.667 (1.571, 13.87) | ||
| Bile exosomal ENST00000517758.1 | 0.041 | 3.000 (1.046, 8.603) | ||
CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; CCA, cholangiocarcinoma; OR, odds ratio, CI, confidential interval.