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. 2022 Aug 24;12:957287. doi: 10.3389/fcimb.2022.957287

Figure 2.

Figure 2

Effect of dimethyl fumarate (DMF), standard treatment and standard treatment with DMF on Mtb loads in the infected murine lungs after 4 (A) and 8 weeks of treatment (B). Mice were infected intranasally as described in Methods and treatment began after 4 weeks of infection. Murine lung homogenates were used for CFU, MPN and MPN_CSN assays. (C) Resuscitation indices. Data shown as means ± STDV (N = 7) (B). The resuscitation indices were calculated using the following formula: RI= log10 (MPN_CSN ml-1) – log10 (CFU ml-1). PEG, control PEG 400 group; DMF, dimethyl fumarate group; RHZ, rifampicin, isoniazid and pyrazinamide group; and DRHZ, rifampicin, isoniazid, pyrazinamide and dimethyl fumarate group; Ns, non-significant; p > 0.05; *p < 0.05; ***p < 0.001; ****p < 0.0001 unpaired t-test.