TABLE 3.
Detailed quality assessment of the included studies using the Cochrane risk-of-bias tool, version 2.
| First author (year) | Randomization process | Intervention adherence | Missing outcome data | Outcome measurement | Selective reporting | Overall RoB |
|---|---|---|---|---|---|---|
| Berman (2004) | L | L | L | L | L | L |
| Lee (2011) | S a | L | S b | L | L | S |
| Cordero (2013) | S a | L | L | L | L | S |
| Lesser (2013) | S a | L | L | L | L | S |
| Castro-Marrero (2015) | S a | L | L | L | L | S |
| Fukuda (2015) | L | L | L | L | L | L |
| Peel (2015) | L | L | L | L | L | L |
| Sanoobar (2016) | S a | L | L | L | L | S |
| Di Pierro (2017) | L | L | L | S c | L | L |
| Morikawa (2019) | S a | L | L | L | L | S |
| Mizuno (2020) | S a | L | L | L | L | S |
| Mousavi (2020) | L | L | L | L | L | L |
| Castro-Marrero (2021) | L | L | L | L | L | L |
CoQ10, coenzyme Q10; H, high risk of bias; L, low risk of bias; RoB, risk of bias; S, some risk of bias
a
These studies didn't provide allocation concealment details.
b
This study excluded five subjects from the CoQ10 group because their blood levels of CoQ10 failed to increase over the study course.
c
An open-label study. The participants were aware of the intervention they received.