Figure 1.

Typical regional cerebral [¹⁸F]fluorodeoxyglucose (¹⁸F-FDG) hypo-metabolism patterns in Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). Patterns are presented as z score maps based on significantly hypo-metabolic voxels relative to non-demented comparison population. AD pattern of glucose hypo-metabolism involves predominantly temporoparietal association cortices, posterior cingulate, and precuneus. In advanced disease, prefrontal association cortices show additional hypo-metabolism. Primary sensorimotor and visual neocortices are relatively spared. DLB has cortical hypo-metabolism similar to that of AD but with additional involvement of occipital cortex. FTD demonstrates frontal lobar or frontal and temporal polar cortical hypo-metabolism with relative sparing of parietal association cortex and preservation of primary somatomotor and visual cortices. ANT = anterior; INF = inferior; LAT = lateral; MED = medial; POST = posterior; SUP = superior. Reproduced with permission (Bohnen and others 2012).