Figure 5.

Topographic differences between amyloid and neurodegeneration. Alzheimer’s disease versus cognitively normal voxel mapping. Pittsburgh compound B (PiB) (left) statistical parametric mapping (SPM) of PiB retention ratio. MRI (right) voxel-based morphometry (VBM) of MRI gray matter density. Plaque deposition but not gray matter loss is seen in the prefrontal cortex while gray matter loss but not plaque deposition is seen in the medial and basal temporal lobes. Reproduced with permission (Jack and others 2008).