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. 2022 Aug 24;9:957549. doi: 10.3389/fmolb.2022.957549

FIGURE 3.

FIGURE 3

Principal Component-Canonical Variates Analysis (PC-CVA) showing system-wide metabolite profile differences between genotype at rest and after exercise. (A) Scores plot of Canonical Variate 1 (CV1) vs. Canonical Variate 2 (CV2). Each point (circle, square or triangle) represents a single sample [WT-Rest (n = 8), WT-Ex (n = 9), DKI-Rest (n = 10), DKI-Ex (n = 9)]. The mean (x) of each group is surrounded by a 95% confidence interval of the mean (full-line circles) and 95% confidence interval of membership in each sample group (dashed-line circles). Sample group means are considered significantly different when the 95% confidence interval of the means do not overlap. (B) The loading plot shows the influence (model coefficient value) of each metabolite that significantly (p < 0.05) contributes to the separation observed in the scores plot. The direction of the coefficient vector maps directly to the direction of the data points in the scores plot relative to the origin.