Table 3.
Comparison between RA Patients and Non-RA Patients at Baseline.
| RA patients (n=51) | Non-RA patients (n=49) | p value | |
|---|---|---|---|
| Age (yr) | 69.9±1.3 71.0 [64.0-76.0] |
65.1±2.9 67.0 [59.0-76.0] |
0.1843 |
| Number of male/female | 5/46 | 2/47 | 0.4367 |
| Postmenopausal (%) | 50 (98.0) | 43 (87.8) | 0.0572 |
| Body mass index (kg/m2) | 20.7±0.5 20.0 [18.3-22.6] |
21.0±0.4 20.4 [18.6-23.4] |
0.4888 |
| Prednisolone usage (%) | 26 (51.0) | 42 (85.7) | 0.0002 |
| Daily prednisolone-equivalent dose (mg/day) | 4.6±0.5 5.0 [2.0-5.0] |
8.2±1.2 5.0 [4.0-10.0] |
0.0223 |
| Bone mineral density (g/cm2) | 0.74±0.01 0.74 [0.65-0.84] |
0.77±0.02 0.78 [0.69-0.84] |
0.1638 |
| Pre-denosumab treatment, no. (%) | |||
| Bisphosphonates | 30 (58.9) | 30 (70) | 0.8405 |
| Teriparatide | 4 (10) | 6 (10) | 0.5208 |
| Vitamin D | 6 (88.9) | 2 (0) | 0.2695 |
| Vitamin K | 1 (33.3) | 2 (0) | 0.6136 |
| SERM | 1 (2.2) | 2 (10) | 0.6136 |
| Baseline of bone turnover markers | |||
| NTx (nmolBCE/L) | 16.7±0.9 15.2 [12.5-21.1] |
15.9±0.9 13.3 [11.4-19.5] |
0.2926 |
| TRACP-5b (mU/dL) | 287.5±23.7 258.0 [169.0-368.0] |
194.3±36.3 215.0 [114.0-285.5] |
0.0505 |
| P1NP (µg/L) | 37.5±4.5 27.4 [20.7-46.6] |
29.4±4.0 24.1 [12.7-36.1] |
0.0127 |
| BAP (µg/L) | 16.2±2.0 13.4 [10.4-17.9] |
10.9±0.8 10.1 [8.1-11.7] |
0.0001 |
| OC (ng/mL) | 6.8±0.4 6.1 [4.8-8.0] |
7.3±0.9 5.7 [3.7-8.2] |
0.4093 |
| Change of bone turnover markers (%) | |||
| Δ NTx | -14.6±5.2 -23.5 [-40.8- 7.2] |
-22.5±5.0 -30.6 [-41.7- -6.7] |
0.2327 |
| Δ TRACP-5b | -42.4±7.6 -60.5 [-75.7- -29.4] |
-35.8±8.2 -53.0 [-68.8- -9.9] |
0.3545 |
| Δ P1NP | -38.7±5.2 -43.4 [-66.6- -20.3] |
-19.9±9.4 -41.6 [-67.4- 7.4] |
0.4683 |
| Δ BAP | -25.8±5.0 -31.9 [-45.8- -16.0] |
-2.3±20.0 -19.8 [-36.3- -10.8] |
0.0770 |
| Δ OC | 10.9±22.2 -27.3 [-44.5- 5.8] |
63.5±47.8 -26.0 [-50.5- 4.1] |
0.5658 |
RA: rheumatoid arthritis, SERM: selective estrogen receptor modulators, NTx: N-telopeptide crosslinked of type I collagen, TRACP-5b: tartrate-resistant acid phosphatase isoform 5b, P1NP: procollagen type I N-terminal peptide, BAP: bone alkaline phosphatase, OC: osteocalcin, Δ: the rate of change during 12 months