Table 5.
Univariate and Multivariate Analysis of Characteristics Associated with Bone Mineral Density Response to Denosumab: Analysis with Change of Bone Metabolism Markers.
| Characteristics | Change of bone mineral density | ||||
|---|---|---|---|---|---|
| Univariate model | Multivariate model | ||||
| β | p value | R2 | β | p value | |
| Age | -0.0031 | 0.00067 | 0.103 | -0.0042 | 0.0006 |
| Female | -0.0132 | 0.76689 | 0.030 | ||
| Body mass index | 0.0047 | 0.17990 | 0.008 | ||
| Prednisolone dose at baseline | -0.0039 | 0.03385 | 0.035 | -0.0113 | 0.0016 |
| Δ NTx | -0.00064 | 0.07768 | 0.022 | -0.0013 | 0.0264 |
| Δ TRACP-5b | 0.00021 | 0.30230 | 0.001 | ||
| Δ P1NP | 0.00012 | 0.2457 | 0.004 | ||
| Δ BAP | 0.00029 | 0.40372 | 0.086 | ||
| Δ OC | 0.00004 | 0.78455 | 0.029 | ||
NTx: N-telopeptide crosslinked of type I collagen, TRACP-5b: tartrate-resistant acid phosphatase isoform 5b, P1NP: procollagen type I N-terminal peptide, BAP: bone alkaline phosphatase, OC: osteocalcin, Δ: the rate of change during 12 months