Table 6.
Univariate and Multivariate Analysis of Characteristics Associated with Bone Mineral Density Response to Denosumab: Analysis with Bone Metabolism Markers at Baseline.
| Characteristics | Change of bone mineral density | ||||
|---|---|---|---|---|---|
| Univariate model | Multivariate model | ||||
| β | p value | R2 | β | p value | |
| Age | 0.1041 | 0.07575 | 0.0325 | ||
| Female | 3.072 | 0.26883 | 0.0127 | ||
| Body mass index | 0.3970 | 0.07448 | 0.0328 | 0.476 | 0.02892 |
| Prednisolone dose at baseline | -0.1402 | 0.22493 | 0.0153 | ||
| NTx | 0.2677 | 0.02035 | 0.0554 | ||
| TRACP-5b | 0.005648 | 0.18122 | 0.0185 | ||
| P1NP | 0.04703 | 0.04201 | 0.0437 | ||
| BAP | 0.04707 | 0.45998 | 0.0058 | ||
| OC | 0.2716 | 0.0667 | 0.035 | ||
NTx: N-telopeptide crosslinked of type I collagen, TRACP-5b: tartrate-resistant acid phosphatase isoform 5b, P1NP: procollagen type I N-terminal peptide, BAP: bone alkaline phosphatase, OC: osteocalcin