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. 2022 Aug 4;298(9):102326. doi: 10.1016/j.jbc.2022.102326

Figure 9.

Figure 9

Summary of the effects of type I, type II, and the mutant peptides on SAKcaC.A, comparisons of the inhibitory effects for type I, type II, and the mutant peptides on SAKcaC. The inhibitory effects were normalized to GsMTx4. Normalized inhibition (%) = [Inhibited(peptide)/Inhibited(GsMTx4)] × 100. B, comparisons of diffusion rates for type I, type II, and the mutant peptides on SAKcaC. The diffusion rates were normalized to GsMTx4. Diffusion rates (%) = (Diffusion rate(peptide)/Diffusion rate(GsMTx4)) × 100. (n = 4–11). &p < 0.05 versus GsMTx4, ∗p < 0.05, ∗∗p < 0.005, ∗∗∗p < 0.001 versus Pept 01. ##p < 0.01, ###p < 0.0001 versus Pept 02. N, no diffusion rate; ns, no significant difference. Intracellular calcium ([Ca2+]i) was 1 mM. SAKcaC was recorded from the CHO-expressing system. CHO, Chinese hamster ovary; SAKcaC, stretch-activated big potassium channel.