Table 2. Associations of Childhood Adversity With Phenotypic Age Acceleration and Mediation Proportion of Childhood Adversity in Phenotypic Age Acceleration Attributed to Unhealthy Lifestyle.

Childhood adversity	β (95% CI)			Mediation proportion, % (95% CI)d	P value
	Model 1a	Model 2b	Model 3c
Physical neglect	0.415 (0.340 to 0.490)	0.233 (0.157 to 0.308)	0.221 (0.146 to 0.296)	11.8 (8.8 to 16.0)	<.001
Emotional neglect	0.206 (0.139 to 0.273)	0.086 (0.020 to 0.153)	0.012 (−0.054 to 0.077)	52.1 (39.3 to 77.0)	<.001
Sexual abuse	0.377 (0.278 to 0.475)	0.278 (0.180 to 0.376)	0.174 (0.077 to 0.271)	34.8 (27.5 to 47.0)	<.001
Physical abuse	0.418 (0.347 to 0.489)	0.302 (0.231 to 0.373)	0.199 (0.128 to 0.269)	32.2 (27.1 to 39.0)	<.001
Emotional abuse	0.349 (0.272 to 0.426)	0.222 (0.145 to 0.299)	0.124 (0.048 to 0.201)	36.9 (30.3 to 48.0)	<.001
Cumulative childhood adversity score (0-5)	0.186 (0.161 to 0.211)	0.117 (0.092 to 0.142)	0.076 (0.051 to 0.100)	NA	NA
0	1 [Reference]	1 [Reference]	1 [Reference]	NA	NA
1	0.164 (0.098 to 0.231)	0.100 (0.034 to 0.166)	0.065 (−0.001 to 0.130)	31.4 (21.1 to 53.0)	<.001
2	0.272 (0.182 to 0.362)	0.147 (0.057 to 0.237)	0.064 (−0.025 to 0.153)	42.1 (31.5 to 65.0)	<.001
3	0.523 (0.402 to 0.645)	0.331 (0.209 to 0.452)	0.200 (0.080 to 0.321)	34.1 (26.9 to 45.0)	<.001
4	0.726 (0.558 to 0.894)	0.457 (0.289 to 0.624)	0.296 (0.130 to 0.462)	30.7 (24.1 to 40.0)	<.001
5	1.488 (1.189 to 1.788)	1.050 (0.751 to 1.349)	0.833 (0.537 to 1.129)	20.9 (16.5 to 27.0)	<.001

Abbreviation: NA, not applicable.

^a Model 1 was adjusted for sex.

^b Model 2 was further adjusted for race and ethnicity, educational level, occupation, Townsend Deprivation Index, maternal smoking around birth, and history of cardiovascular disease and cancer based on model 1.

^c Model 3 was further adjusted for unhealthy lifestyle score based on model 2.

^d The model included sex and unhealthy lifestyle score.