Table 3. Outcomes of Patients According to the Dexamethasone Group in the Overall Study Sample .
| Outcome | Standard of care dexamethasone (n = 276) | High-dose dexamethasone (n = 270) | Estimate (95% CI) | |
|---|---|---|---|---|
| Difference | Hazard ratioa | |||
| Overall survival at 60 d, Kaplan-Meier estimate, % (95% CI) | 72.2 (66.2 to 82.6) | 73.0 (67.8 to 76.5) | 0.8 (–6.8 to 8.4) | 0.96 (0.69 to 1.33) |
| Secondary end points | ||||
| Viral load evolution, mean slope (SE) | 0.31 (0.08) | 0.46 (0.06) | 0.15 (–0.05 to 0.35) | NC |
| HAI at 28 d, No. (%) | 75 (27.2) | 81 (30.0) | 2.8 (–4.8 to 10.4) | 1.10 (0.85 to 1.44) |
| Alive free of IMV at 28 d, median (IQR), d | 28 (6 to 28) | 28 (9 to 28) | 1.0 (–2.9 to 0.9) | NC |
| Alive free of KRT at day 28, median (IQR), d | 28 (14 to 28) | 28 (16 to 28) | 0.8 (–2.4 to 0.8) | NC |
| LOS, median (IQR), d | ||||
| ICU | 9 (5 to 15) | 8 (5 to 15) | 0.1 (–3.0 to 2.7) | NC |
| Hospital | 15 (10 to 24) | 16 (11 to 27) | 1.3 (–4.4 to 1.8) | NC |
| SOFA evolution: mean slope (SE) | 0.10 (0.01) | 0.09 (0.01) | –0.01 (–0.05 to 0.03) | NC |
| ≥1 Adverse event, No. (%) | 208 (75.4) | 202 (74.8) | –0.6 (–7.8 to 6.7) | 0.99 (0.90 to 1.09) |
Abbreviations: HAI, health care–associated infection; ICU, intensive care unit; IMV, invasive mechanical ventilation; KRT, kidney replacement therapy; LOS, length of stay; NC, not calculated; VAP, ventilator-associated pneumonia.
a
Hazard ratios were stratified on the IMV strata.