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. Author manuscript; available in PMC: 2022 Sep 7.
Published in final edited form as: J Hepatol. 2022 Apr 19;77(3):619–631. doi: 10.1016/j.jhep.2022.04.010

Fig. 7. Restoration of VMP1 in Vmp1 KO mice improves VLDL secretion and ablates hepatic steatosis and liver injury.

Fig. 7.

(A) Serum TG and cholesterol were measured in H-WT, H-Vmp1 KO and H-Vmp1 KO/KI mice at 2 weeks post AAV. (B) Mice were fasted for 4 hours followed by Pluronic™ F-127 injection for another 4 hours. Pooled serum samples were subjected to FPLC analysis of lipoproteins (n = 5), and each corresponding fraction was subjected to immunoblot analysis for APOB. (C) VLDL secretion was assessed in mice after VMP1 restoration. (D) Representative images of gross livers, H&E and Oil Red O staining of mouse livers. (E-H) Hepatic TG (E), body weight (F), liver/body weight ratio (G) and ALT (H) were quantified. Data represent mean ± SEM (n = 5–7). *p <0.05; ***p <0.001 (Unpaired Student’s t test for 2 group comparison or one-way ANOVA with Holm-Sidak post hoc test for multigroup comparison).