Skip to main content
. Author manuscript; available in PMC: 2022 Sep 7.
Published in final edited form as: J Hepatol. 2022 Apr 19;77(3):619–631. doi: 10.1016/j.jhep.2022.04.010

Fig. 8. Decreased VMP1 in human NAFLD and overexpression of VMP1 alleviates diet-induced steatosis in mice.

Fig. 8.

(A) Total lysates from human livers were subjected to immunoblot analysis. (B) Representative images of VMP1 IHC and H&E staining of normal and NAFLD/NASH patient livers. (C) H-WT mice were fed with CDAHFD for 6 weeks. Protein and mRNA levels of VMP1 in mouse livers were measured by immunoblot and qPCR analysis. (D) Scheme of CDAHFD-induced NASH in mice. (E) Hepatic concentrations of PC and PE, (F) TG and cholesterol and (G) H&E staining of liver tissues. (H) VLDL secretion was assessed in WT and VMP1 KI mice. Data represent mean ± SEM (n = 5–7). *p <0.05; ***p <0.001 (Unpaired Student’s t test for 2 group comparison or one-way ANOVA with Holm-Sidak post hoc test for multigroup comparison). NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.