TABLE 1.
Biochemical indices of the “Newborn-screen Group” and “Clinical diagnosed Group” at first detection.
| Indices | Newborn-screen group (average ± SD, positive rate) | Reference intervals for 10–30 days | Clinical diagnosed group (average ± SD, positive rate) | Reference intervals for 1–12 months |
|---|---|---|---|---|
| TP (g/L)↓a | 44.02 ± 6.87 (62.2%) | 41.0–63.0 | 46.13 ± 8.26 (91%) | 57.0–80.0 |
| ALB (g/L)↓ | 30.29 ± 5.55 (54.1%) | 28.0–44.0 | 31.8 ± 5.65 (58.56%) | 32.0–52.0 |
| GLB (g/L)↓ | 13.72 ± 2.55 (100.00%) | 20.0–40.0 | 14.34 ± 3.94 (90.99%) | 20.0–40.0 |
| TBil (umol/L)↑b | 122.33 ± 69.30 (91.9%) | 5.0–21.0 | 139.88 ± 66.05 (94.59%) | 5.0–21.0 |
| DBil** (umol/L)↑ | 41.79 ± 29.83 (91. 9%) | 0–5.1 | 66.08 ± 38.28 (95.5%) | 0–5.1 |
| IBil (umol/L)↑ | 80.54 ± 51.19 (86.49%) | 1.0–20.0 | 73.87 ± 44.91 (90.09%) | 1.0–20.0 |
| ALT** (U/L)↑ | 27.05 ± 13.84 (10.8%) | 5–50 | 44.83 ± 25.73 (34.23%) | 5–50 |
| AST** (U/L)↑ | 69.73 ± 40.95 (35.1%) | 25–75 | 121.93 ± 63.71 (90.99%) | 15–60 |
| CHE (U/L)↓ | 5124 ± 1589 (70.3%) | 5300–11300 | 4689.98 ± 1373.16 (78.38%) | 5300–11300 |
| GGT (U/L)↑ | 189.81 ± 90.19 (94.59%) | 8–57 | 188.72 ± 99.97 (94.59%) | 8–57 |
| ALP (U/L)↑ | 845.48 ± 438.66 (86.49%) | 42–362 | 952.53 ± 512.09 (90.09%) | 42–362 |
| ADA** (U/L)↑ | 13.27 ± 5.93 (37.84%) | 0–15 | 22.22 ± 12.07 (66.67%) | 0–15 |
| TBA** (umol/L)↑ | 190.58 ± 87.89 (83.78%) | 0–12 | 253 ± 101.73 (95.88%) | 0–12 |
| urea** (mmol/L)↓ | 3.73 ± 1.37 (4%) | 1.79–6.43 | 2.82 ± 1.08 (12.12%) | 1.79–6.43 |
| Uric Acid* (mmol/L)↓ | 207.6 ± 73.6 (16%) | 155–357 | 164.65 ± 63.59 (23.47%) | 155–357 |
| LDH** (U/L)↑ | 250.25 ± 147.75 (4.00%) | 180–430 | 473.94 ± 250.57 (65.98%) | 180–430 |
| TG (mmol/L)↑ | 1.69 ± 1.23 (44.00%) | <1.7 | 1.65 ± 0.74 (41.24%) | <1.7 |
| TCH* (mmol/L)↑ | 3.88 ± 1.30 (4.00%) | 3–5.7 | 4.52 ± 1.33 (24.74%) | 3–5.7 |
| amylase** (U/L)↓ | 19.14 ± 17.92 (56%) | 28–100 | 13.2 ± 12.0 (52.58%) | 28–100 |
| Lactate** (mmol/L)↑ | 2.22 ± 1.20 (68.18%) | 0.5–1.6 | 4.2 ± 1.95 (93.68%) | 0.5–1.6 |
| AFP (ng/mL)↑ | 113734 ± 127414 (84.38%) | 0–20 | 201751 ± 465135 (92%) | 25–100 (1–3M); 25–100 (>3M) |
| HB** (g/L)↓ | 115 ± 17 (31.82%) | 170–200 | 96.93 ± 12.97 (80.85%) | 110–155 |
| Ammonia** (umol/L)↑ | 48.26 ± 34.33 (73.68%) | 9–30 | 85.94 ± 35.03 (95.92%) | 9–30 |
| PT (s)↑ | 14.67 ± 2.64 (38.46%) | 9–14 | 15.94 ± 4.02 (62.5%) | 9–14 |
| TT*(s)↑ | 21.65 ± 2.05 (30.00%) | 15–22 | 24.95 ± 3.96 (66.67%) | 15–22 |
| APTT (s)↑ | 48.33 ± 18.67 (92.31%) | 23–38 | 52.55 ± 15.05 (36.78%) | 23–38 |
**means the difference in the two groups is significant at the 0.01 level.
*means the difference in the two groups is significant at the 0.05 level.
↓ameans the positive rate is calculated for the values lower than the normal range.
↑bmeans the positive rate is calculated for the values higher than the normal range.
TP, total protein; ALB, albumin; GLB, globulin; TBil, total bilirubin; DBil, direct bilirubin; IBil, indirect bilirubin; ALT, alanine aminotransferase; AST, aspartate amino transferase; CHE, cholinesterase; GGT, gamma-glutamyl transpeptidase; ALP, alkaline phosphatase; ADA, adenosine deaminase; TBA, total bile acid; LDH, lactate dehydrogenase; TG, triglyceride; TCH, total cholesterol; AFP, alpha fetoprotein; HB, hemoglobin; PT, prothrombin time; TT, thrombin time; APTT, activate partial thrombin activity time.