Table 4.
The effect size of secondary outcomes included in the review.
| Outcome/Subgroup | No. of studies | No. of animals | Effect Estimate | p value | Heterogeneity, I2 (p value) |
|---|---|---|---|---|---|
| Fibrosis | 4 | 97 | -0.17 [-1.47, 1.14] | 0.80 | 87.81% (p < 0.00) |
| Cardiomyocyte CSA (mm) | 4 | 93 | -1.10 [-2.24, 0.03] | 0.06 | 81.80% (p < 0.00) |
| Heart rate | 4 | 113 | -0.69 [-1.42,0.03] | 0.06 | 70.56% (p = 0.001) |
| IL-6 levels | 6 | 149 | 5.66 [3.25, -8.06] | 0.001 | 93.46% (p = 0.00) |
| dP/dT max (mmHg/sec) | 3 | 35 | -0.61 [-1.76, 0.53] | 0.29 | 66.99% (p = 0.05) |
| dP/dt min (mmHg/sec) | 3 | 35 | 0.84 [0.19, 1.50] | 0.01 | 2.24% (p = 0.36) |