Figure 11.

BAI obtained with eq 8 and represented as a color plot projected on the surface residues of the COE3 antibody. We show results for HIS⁺ (left) and HIS⁰ (right) buffer molecules, and these are compared with the SAP color plots (middle panel) for the same protein (Reprinted adapted with permission from ref (44). Copyright 2010 American Chemical Society). The top and bottom panels correspond to the front and side views. Equivalent regions on the BAI and SAP plots are indicated by stars (for the front view) and circles (for the side view) using the same color. The aggregation-prone regions (shown in red) on the SAP plot feature the strongest adsorption of the histidine buffer (see BAI plots).