. 2022 Aug 23;19(9):3085–3099. doi: 10.1021/acs.molpharmaceut.2c00124

Table 3. Calculated Nominal UWL Thicknesses Using the Stirring Rate Method.

stirring rate (rpm)	calculated nominal UWL thickness (μm)
	ATZ		ATZ with BSA		CTZ with BSA
	free drug	aggregates	free drug	aggregates	free drug	aggregates
60	4518^a	37.8^a	1901.7^a	15.5^a	14,842^a	12.6
100	3058^a	25.6^a	1550.1^a	12.7^a	10,831^a	9.2
150	2243	18.8	1317.9	10.8	8435	7.1
300	1320	11.0	998.6	8.2	5501^a	4.6^a
500	894	7.5	814.0	6.7	4014^a	3.4^a
1000	526	4.4	616.8	5.1	2618^a	2.2^a

Experiments not performed at these conditions. Values of α and 1/K were determined (eqs S21 and S19) using 1/Papp values obtained from experimental data collected at different stirring rates, and nominal UWL thicknesses for the free drug and aggregates were then calculated using eqs 20 and 22.