Table 3:
Rate (95% CI) of screening mammograms followed by biopsy (per 1000 screens) adjusted for age, comorbidity score and Breast Cancer Surveillance Consortium registry
| Age at screen, years | Overall N (denominator) | Any biopsy | p-trend* | Fine needle aspiration | p-trend* | Core biopsy | p-trend* | Surgical biopsy | p-trend* |
|---|---|---|---|---|---|---|---|---|---|
| 66–74 | 304334 | 15.7 (14.8, 16.8) | <0.001 | 1.6 (1.3, 2.0) | 0.50 | 11.2 (10.4, 12.1) | <0.001 | 6.5 (5.9, 7.2) | 0.52 |
| 75–84 | 190180 | 14.5 (13.5, 15.6) | 1.5 (1.2, 1.9) | 10.0 (9.2, 10.9) | 6.6 (5.9, 7.4) | ||||
| 85–94 | 30346 | 13.2 (11.3, 15.4) | 1.5 (1.0, 2.3) | 9.2 (7.7, 11.1) | 6.2 (5.0, 7.9) | ||||
| Charlson Comorbidity Score (CCS) | |||||||||
| 0 | 379958 | 14.4 (13.5, 15.3) | <0.001 | 1.6 (1.3, 1.9) | 0.41 | 10.1 (9.4, 10.8) | <0.001 | 6.3 (5.7, 6.9) | <0.001 |
| 1 | 105889 | 16.6 (15.2, 18.1) | 1.5 (1.1, 2.0) | 11.9 (10.7, 13.2) | 6.8 (6.0, 7.8) | ||||
| 2+ | 39013 | 19.0 (16.9, 21.5) | 1.7 (1.1, 2.5) | 13.4 (11.6, 15.5) | 8.3 (6.9, 9.9) | ||||
| Age at screen=66–74 years | |||||||||
| CCS=0 | 227031 | 14.9 (14.1, 15.7) | <0.001 | 1.7 (1.4, 1.9) | 0.40 | 10.5 (9.8, 11.2) | <0.001 | 6.2 (5.7, 6.8) | <0.001 |
| CCS=1 | 58292 | 17.0 (15.7, 18.3) | 1.5 (1.2, 1.9) | 12.5 (11.4, 13.6) | 6.5 (5.8, 7.4) | ||||
| CCS=2+ | 19011 | 21.1 (19.0, 23.5) | 1.4 (0.9, 2.1) | 15.3 (13.5, 17.4) | 9.4 (8.0, 11.0) | ||||
| Age at screen=75–84 years | |||||||||
| CCS=0 | 132603 | 13.8 (13.0, 14.7) | 0.003 | 1.4 (1.2, 1.7) | 0.02 | 9.6 (8.9, 10.3) | 0.09 | 6.4 (5.8, 7.1) | 0.55 |
| CCS=1 | 40916 | 16.4 (15.0, 17.8) | 1.5 (1.1, 2.0) | 11.4 (10.2, 12.6) | 7.3 (6.4, 8.3) | ||||
| CCS=2+ | 16661 | 16.7 (14.7, 18.9) | 2.2 (1.5, 3.1) | 10.9 (9.4, 12.7) | 6.8 (5.6, 8.3) | ||||
| Age at screen=85–94 years | |||||||||
| CCS=0 | 20324 | 12.9 (11.3, 14.6) | 0.79 | 1.6 (1.1, 2.2) | 0.74 | 9.0 (7.8, 10.5) | 0.51 | 6.2 (5.1, 7.4) | 0.95 |
| CCS=1 | 6681 | 14.2 (11.6, 17.4) | 1.2 (0.6, 2.4) | 9.7 (7.6, 12.3) | 6.5 (4.8, 8.8) | ||||
| CCS=2+ | 3341 | 13.4 (10.0, 17.9) | 1.3 (0.6, 3.2) | 10.1 (7.3, 14.1) | 6.3 (4.1, 9.6) | ||||
*
The p-values testing for trend across age group and across comorbidity score are based on models that do not include an interaction between age and comorbidity. The p-values testing for trend across comorbidity within each age group are based on models with an interaction between age group and comorbidity group.
CCS: Charlson Comorbidity Score, CI: Confidence Interval.