Table 3.
Univariate and multivariate Cox analysis (Overall Survival) of prognostic covariates in patients with pancreatic cancer.
| Characteristics | Total(N) | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| T stage (T3 & T4 vs. T1 & T2) | 176 | 2.023 (1.072–3.816) | 0.030 | 1.057 (0.516–2.166) | 0.879 |
| N stage (N1 vs. N0) | 173 | 2.154 (1.282–3.618) | 0.004 | 1.524 (0.818–2.838) | 0.184 |
| M stage (M1 vs. M0) | 84 | 0.756 (0.181–3.157) | 0.701 | ||
| Radiation therapy (Yes vs. No) | 163 | 0.508 (0.298–0.866) | 0.013 | 0.430 (0.227–0.813) | 0.009 |
| Primary therapy outcome (PR & CR vs. PD&SD) | 139 | 0.425 (0.267–0.677) | <0.001 | 0.524 (0.315–0.871) | 0.013 |
| Gender (Male vs. Female) | 178 | 0.809 (0.537–1.219) | 0.311 | ||
| Race (White vs. Asian & Black or African American) | 174 | 1.161 (0.582–2.318) | 0.672 | ||
| Age (>65 vs. ≤65) | 178 | 1.290 (0.854–1.948) | 0.227 | ||
| Residual tumor (R1 & R2 vs. R0) | 164 | 1.645 (1.056–2.561) | 0.028 | 1.503 (0.887–2.546) | 0.130 |
| Histologic grade (G3 & G4 vs. G1 & G2) | 176 | 1.538 (0.996–2.376) | 0.052 | ||
| Anatomic neoplasm subdivision (Other vs. Head of Pancreas) | 178 | 0.417 (0.231–0.754) | 0.004 | 0.559 (0.265–1.178) | 0.126 |
| PLAAT4 (High vs. Low) | 178 | 1.943 (1.279–2.953) | 0.002 | 1.806 (1.080–3.020) | 0.024 |