Fig. 4. Luciferase mRNA delivery in vivo. (a) Whole body IVIS images of luciferase signal in mice after administration of LNPs. (b) Isolated organ IVIS images of luciferase signal, showing delivery to the liver and spleen. (c) Quantification of luciferase signal in the whole-body, liver, and spleen. Normalized total flux was averaged. n = 4 mice per treatment group. **p < 0.01.