Optimization of the reaction conditions^a,b.

Entry	Cat.	P ligand	Base	Solvent	Yieldb (%)
1	PdCl2	XPhos	K3PO4	DMF	40
2	Pd2(dba)3	XPhos	K3PO4	DMF	10
3	Pd(dppf)Cl2	XPhos	K3PO4	DMF	35
4	Pd(PPh3)2Cl2	XPhos	K3PO4	DMF	10
5	Pd(acac)2	XPhos	K3PO4	DMF	19
6	Pd(OAc)2	XPhos	K3PO4	DMF	58
7	Pd(OAc)2	dppe	K3PO4	DMF	5
8	Pd(OAc)2	PPh3	K3PO4	DMF	6
9	Pd(OAc)2	dppp	K3PO4	DMF	15
10	Pd(OAc)2	JohnPhos	K3PO4	DMF	20
11	Pd(OAc)2	SPhos	K3PO4	DMF	32
12	Pd(OAc)2	Ruphos	K3PO4	DMF	30
13	Pd(OAc)2	XPhos	K2HPO4	DMF	50
14	Pd(OAc)2	XPhos	Cs2CO3	DMF	23
15	Pd(OAc)2	XPhos	NaHCO3	DMF	25
16	Pd(OAc)2	XPhos	Et3N	DMF	21
17	Pd(OAc)2	XPhos	K3PO4	DMSO	43
18	Pd(OAc)2	XPhos	K3PO4	DMA	31
19	Pd(OAc)2	XPhos	K3PO4	Dioxane	Trace
20	Pd(OAc)2	XPhos	K3PO4	MeCN	58
21	Pd(OAc)2	XPhos	K3PO4	EtOH	46
22	Pd(OAc)2	XPhos	K3PO4	iPrOH	72
23	Pd(OAc)2	XPhos	K3PO4	tAmOH	63

^a1a (0.36 mmol), 2a (0.30 mmol), cat. Pd (5 mo%), ligand (5 mo%), base (0.3 mmol), solvent (2.0 mL), 80 °C, 16 h, under N₂.

^bIsolated yield.