Table 1.

Detailed Description of Procedures in the RCT comparing iPrEP to Usual Care.

Procedures	Details
UT-HEARTS referral	•Prior to enrollment, individuals are screened in-person and are offered a referral to the UT-HEARTS program. Questions assessing eligibility for the study are imbedded within the screening form. •Women who accepted the referral were contacted by a UT-HEARTS coordinator following the initial study visit.
Pre-test	• The pre-test assesses: • Socio-demographics (age, education level, sexual orientation, income level, and employment status) • Behaviors (sexual activity and substance use) – based on the risk assessment battery (RAB) • Predictive data (risk perception and willingness for PrEP uptake) •Study data includes phone numbers, physical and email addresses for follow-up
RCT assignment	Intervention Group: •Women will receive the iPrEP intervention on a tablet device •iPrEP uses qualitative themes •iPrEP is divided into sections addressing factors with historical success at increasing PrEP adherence [42] •Scales chosen to measure themes and sections are retained from the original HPTN 073 instrument •Scales are modified (in some cases) for cultural competency and tailoring to women
	Control Group: • Women will receive usual care • An assessment visit with an ED-assigned social worker who specializes in substance use • Social worker will offer a list of substance abuse treatment referral agencies, but no intervention • Study procedures will not interfere with the protocol for social workers
Post-test	•Women who are randomized will complete a post-test after the RCT. •The post-test will assess predictive data in two areas risk perception and willingness for PrEP uptake.
Outcomes	Primary: •Increased willingness for PrEP uptake post intervention and at follow-up assessments (1, 3, and 6 months). •Stimulate an initial PrEP clinic visit within a 6-month period. Secondary: •Decrease high risk sex 6-months post intervention measured by TLFB [38,39], RAB [[35], [36], [37]] •Decrease in substance use [[43], [44], [45], [46], [47]] measured by TLFB, and self-report •STI outcome, confirmed via EMR and/or self-report [48,49] •HIV seroconversion within 6 months, confirmed via self-report •Perception of whether the intervention informed decision making (Yes/No format)