Table 1.
Sequence comparison between RVG and loop II of α-bungarotoxin and α-cobratoxin. Bolded residues are conserved among RGP and at least one α-neurotoxin. The underlined residues are those important for mediating nAChR interactions. Snake toxin residues absent in RGP are represented with a dash space holder to facilitate sequence alignments.
| Virus/Toxin | Sequence | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RGP | Y | T | - | I | W | M | P | E | N | P | R | L | G | T | S | C | D | I | F | T | N | S | R | G | K | R | A | S | K | G | 203 |
| α-Bungarotoxin | Y | R | K | M | W | - | - | - | - | - | - | - | - | - | - | C | D | A | F | C | S | S | R | G | K | V | V | E | L | G | 43 |
| α-Cobratoxin | Y | T | K | T | W | - | - | - | - | - | - | - | - | - | - | C | D | A | F | C | S | I | R | G | K | R | V | D | L | G | 40 |