Table 2.
Summary of genes annotated with KO numbers associated with each major enzyme in the pyrimidine metabolism pathway
| EC No. | KO No. | Gene ID | Localization (transit pep.) | Origin | Synechococcus sp. WH5701 Proteins | Gene ID P. chromatophora | |
|---|---|---|---|---|---|---|---|
| Nuclear and chromatophore encoded | 1.17.4.2 | K00527 | MSTRG.18906.1.p1 | Nuclear | Bacterial | – | – |
| K00524 | APP88576.1 | Chromatophore | – | PCH_911314_913644 | |||
| 2.4.2.10 | K13421 | MSTRG.5317.1.p1 | Nuclear | Eukaryotic | –EAQ74889;EAQ76532 | m.76923, m.59611 | |
| K00762 | APP88279.1 | Chromatophore | PCH_574488_575072 | ||||
| 2.7.4.6 | K00940 | MSTRG.7674.2.p1 | Nuclear | Eukaryotic | EAQ76583 | m.102663, m.143874 | |
| MSTRG.13723.1.p1 | Nuclear (mtTP) | Eukaryotic | |||||
| APP88146.1 | Chromatophore | PCH_406754_407299 | |||||
| 2.7.4.9 | K00943 | MSTRG.9240.1.p1 | Nuclear | Eukaryotic | EAQ75333 | m.93602, m.114252 | |
| APP88085.1 | Chromatophore | – | |||||
| 3.5.4.13 | K01494 | MSTRG.7644.1.p1 | Nuclear | Eukaryotic | EAQ75459;EAQ76479 | – | |
| APP88297.1 | Chromatophore | PCH_596488_597081 | |||||
| 4.1.1.23 | K13421 | MSTRG.5317.1.p1 | Nuclear | Eukaryotic | – | m.76923, m.59611 | |
| K01591 | APP88463.1 | Chromatophore | EAQ76096 | PCH_781998_782753 | |||
| 6.3.4.2 | K01937 | MSTRG.26400.1.p1 | Nuclear | Eukaryotic | EAQ76380 | m.39956 | |
| APP88166.1 | Chromatophore | PCH_436530_438125 | |||||
| 6.3.5.5 & 3.5.2.3 | K11540 | MSTRG.13416.1.p1a | Nuclear | Eukaryotic | – | m.4707 | |
| K11541 | MSTRG.9073.1.p1a | Nuclear | Eukaryotic | – | m.143618 | ||
| K01955 | APP88558.1 | Chromatophore | EAQ73983 | PCH_890549_893851 | |||
| K01956 | APP88018.1 | Chromatophore | EAQ75106 | PCH_250855_252036 | |||
| Chromatophore encoded | 1.3.5.2 | K00254 | APP88135.1 | Chromatophore | EAQ76618 | PCH_393519_394685 | |
| 2.1.1.148 | K03465 | APP88298.1 | Chromatophore | – | PCH_597091_597813 | ||
| 2.4.2.9 | K00761 | APP88061.1 | Chromatophore | EAQ73733 | PCH_305134_305784 | ||
| 2.7.4.22 | K09903 | APP88634.1 | Chromatophore | EAQ74917 | PCH_983960_984673 | ||
| 2.7.4.25 | K13799 | APP88384.1 | Chromatophore | EAQ76776 | PCH_688242_689084 | ||
| 3.5.4.1 | K01485 | APP87895.1 | Chromatophore | EAQ73641;EAQ74433 | PCH_89917_91152 | ||
| Nuclear encoded | 1.3.98.1 | K00226 | MSTRG.1224.1.p1a | Nuclear | Eukaryotic | EAQ74251 | m.72251 |
| MSTRG.1225.1.p1 | Nuclear | Eukaryotic | |||||
| 1.17.4.1 | K10807 | MSTRG.3989.1.p1 | Nuclear | Eukaryotic | – | m.19028 | |
| K10808 | MSTRG.12045.1.p1 | Nuclear | Eukaryotic | – | m.79073, m.89037, m.148939, m.53968 | ||
| 2.1.1.45 | K13998 | MSTRG.21233.1.p1 | Nuclear | Eukaryotic | – | m.50936 | |
| MSTRG.27860.1.p1a | Nuclear | Eukaryotic | – | ||||
| 2.1.3.2 | K00609 | MSTRG.21874.1.p1a | Nuclear (crTP) | Uncertain | EAQ75419 | m.86993, m.62292 (crTP) | |
| K11540 | MSTRG.13416.1.p1a | Nuclear | Eukaryotic | – | m.4707 | ||
| K11541 | MSTRG.9073.1.p1a | Nuclear | Eukaryotic | – | – | ||
| 2.4.2.2 & 2.4.2.3 & 2.4.2.4 | K09913 | MSTRG.6408.1.p1 | Nuclear | Uncertain | – | – | |
| MSTRG.6409.1.p1 | Nuclear (crTP) | Uncertain | |||||
| 2.7.1.48 | K00876 | MSTRG.28031.1.p1 | Nuclear (crTP) | Eukaryotic | – | m.65065 | |
| MSTRG.25663.1.p1 | Nuclear | Bacteria | |||||
| 3.1.3.5 | K01081 | MSTRG.17384.1.p1 | Nuclear | Eukaryotic | – | m.15216, m.102769, m.22838, m.28026, m.42900, m.63166 | |
| MSTRG.27764.1.p1 | Nuclear | Eukaryotic | |||||
| K11751 | MSTRG.831.1.p1 | Nuclear | Eukaryotic | – | m.106789, m.5449, m.145463 | ||
| MSTRG.19222.1.p1 | Nuclear | Eukaryotic | |||||
| K24242 | MSTRG.21922.1.p1 | Nuclear (crTP) | Eukaryotic | – | m.63166 (crTP) | ||
| MSTRG.16505.1.p1 | Nuclear | Eukaryotic | m.22838 | ||||
| 3.5.4.5 | K01489 | MSTRG.23658.1.p1a | Nuclear | Eukaryotic | – | m.58556 | |
| 3.6.1.5 | K01510 | MSTRG.21143.1.p1 | Nuclear | Eukaryotic | – | m.107005, m.139053 | |
| 3.6.1.6 | K12304 | MSTRG.971.1.p1 | Nuclear | Eukaryotic | – | m.93542, m.61014 | |
| MSTRG.2459.4.p1 | Nuclear | Eukaryotic | |||||
| 3.6.1.12 | K16904 | MSTRG.9895.1.p1 | Nuclear | Eukaryotic | – | m.73914 | |
| 3.6.1.- | K01519 | MSTRG.11874.1.p1 | Nuclear (crTP) | Eukaryotic | – | m.41123 (crTP) | |
| MSTRG.24583.1.p1 | Nuclear | Eukaryotic | m.104136 | ||||
| 3.6.1.23 | K01520 | MSTRG.27457.1.p1 | Nuclear (crTP) | Eukaryotic | – | m.87559 (crTP) | |
| MSTRG.19767.1.p1 | Nuclear | Eukaryotic | m.118837, m.201858, m.56738 |
KO numbers in italics are associated with multiple enzyme reactions within the Pyrimidine Metabolism pathway.
Chromatophore transit peptides (crTP); mitochondrial transit peptides (mtTP).
a
Protein is 3′ or 5′ partial.