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. 2022 Sep 6;26:42. doi: 10.1186/s40824-022-00288-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — a Mechanism of mesocrystals; (1) alignments by the organic matrix and (2) physical forces, (3) crystalline bridges by epitaxial growth and secondary nucleation, (4) alignments by spatial constraints, (5) oriented attachment, and (6) face selective molecules [113]. b Cryo-TEM (1) image and (2) SAED pattern of the mineralized collagen fibril in the presence of pAsp [117]. c (1) TEM image of mineralized triple-helix protein molecule, (2) and (3) filtered and zoomed images of mineralized triple-helix protein molecules [123], Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim