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. 2022 Sep 6;26:42. doi: 10.1186/s40824-022-00288-0

Table 1.

Distinct advantages and disadvantages of different collagen preparation methods [10], © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

Sources Advantages Disadvantages
Tissue extracted collagen

High yield

No antigenic p-determinant

Potential of disease transmission
Cell synthesized collagen Can be autologous Low yield
Recombinantly produced collagen Low immune response

Low yield

Stability issues

Peptide synthesis produced collagen Exclusion of allogeneic/xenogeneic issues

Low yield

Assembly/registration issues