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. 2022 Sep 7;12:149. doi: 10.1186/s13578-022-00882-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — RRM2 silencing has anti-tumor effects and enhances CD8 + T cells infiltrations in Lewis mice model. Lewis mice were injected with LV-NC and LV-siRRM2 infected LLC cells. a The tumor volumes were measured every 3 days and depicted in the line chart. b, c Representative IVIS spectrum imaging for tumor-bearing mice. The fluorescence radiance comparison between LLC-LV-NC and LLC-LV-siRRM2 groups. d, e Representative fow cytometry of CD4 + and CD8 + T cells in spleens and tumors. Quantitative analysis of CD4 + and CD8 + T cells in spleens and tumors. f, g Representative image of CD4 and CD8 staining for spleens and tumors by IHC. Scale bar: 100 μm. *p < 0.05, **p < 0.01, ns: not significant