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. 2022 Sep 7;22:531. doi: 10.1186/s12887-022-03556-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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fig. 1 — Flow chart of patients enrolled in the SPECS trial.

ND Neurodevelopmental, SPECS Safe pediatric euglycemia after cardiac surgery, STD Standard care, TGC Tight glycemic control. 872 patients were eligible for 3-year-old follow-up, 269 had any follow-up between 30–42.5 months of age, and 214 had in-person testing. ^a 221 patients (97 TGC, 124 STD) without genetic anomaly. ^b 169 patients (72 TGC, 97 STD) without genetic anomaly