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. 2022 Sep 7;19:221. doi: 10.1186/s12974-022-02578-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Foxy-5 potentiates nociceptive sensation, while miR-26a-5p rescues this effect. A Experimental design and treatment at different timepoints. B 50% paw withdraw threshold (PWT) of left hind paw of different treatment groups mice. At the day of 10, 12 and 14, the paw withdrawal thresholds (WTs) of miR-rescue group was significantly higher than those of SNI + miR + Foxy5 group after miR-26a-5p rescue at the 9th day (*p < 0.05, **p < 0.01 compared with SNI + miR + Foxy5 group by Two-way ANOVA followed by Tukey post hoc test, n = 8 in each group). C At the days of 13 and 14, the paw withdrawal thresholds (WTs) of D12 rescue group was significantly higher than those of SNI + miR-26a-5p group (**p < 0.01 compared with SNI + miR-26a-5p group by Two-way ANOVA followed by Tukey post hoc test, n = 8 in each group)