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. 2022 Sep 7;41:267. doi: 10.1186/s13046-022-02482-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Circ_0000098 promotes HCC development and P-gp expression via the miR-383/MCUR1 axis. A-D Flow cytometry analysis (A), clone formation assays (B), migration assays (C), and invasion assays (D) were conducted to detect cell cycle arrest in the indicated cells. E–F Detection of ATP levels in HCC-LM3 (E) and BEL-7404 (F) cells transfected as indicated. G-H RT-qPCR assays were used to detect P-gp expression in HCC-LM3 (G) and BEL-7404 (H) cells transfected as indicated. I-J Detection of ATP levels in HCC-LM3 (I) and BEL-7404 (J) cells transfected as indicated. K-L RT-qPCR assays were used to detect P-gp expression in HCC-LM3 (K) and BEL-7404 (L) cells transfected as indicated. M Detection of P-gp protein expression in sh-1- and sh-NC-transfected HCC-LM3 cells using western blotting analysis (N) The effect of circ_0000098 on extracellular DOX resistance in HCC was detected by CCK-8 assay (O) The expression of circ_0000098 in DOX-resistant patients. *P < 0.05, **P < 0.01, ***P < 0.001