Fig. 1.
Structure and interactions of the SARS-CoV-2 Mpro-nirmatrelvir bound complex. (A) The crystal structure of full-length SARS-CoV-2 Mpro is shown as a cartoon, and bound nirmatrelvir is shown as a stick. (B) The nirmatrelvir-interacting residues of Mpro are shown as lines along with hydrogen bond interactions as yellow dashed lines. (C) A 2D representation showing various types of interactions between Mpro and nirmatrelvir, where various types of intermolecular interactions are labeled in the legend. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)